1164469-60-6
1164469-60-6 结构式
基本信息
常见问题列表
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Alpha-1A adrenergic receptor 3.7 nM (Ki) |
Alpha-1B adrenergic receptor 20 nM (Ki) |
Alpha-1D adrenergic receptor 1.2 nM (Ki) |
Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.
Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
Cell Proliferation Assay
| Cell Line: | PCa cells, PrSC |
| Concentration: | 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) |
| Incubation Time: | 3 days |
| Result: | Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners. |
Western Blot Analysis
| Cell Line: | PCa cells, PrSC |
| Concentration: | 50 μM (E9 cells), 25 μM (PrSC) |
| Incubation Time: | 48 hours |
| Result: | Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC. |
Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.
| Animal Model: | Male athymic mice(7-8 weeks), with E9+PrSC xenograft |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration, daily, for 28 days |
| Result: | Decreased tumor weights. |