1164500-72-4
1164500-72-4 结构式
基本信息
中文别名
化合物 T12074 英文别名
ML 1452-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
Benzoic acid, 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-
所属类别
生物：拮抗剂ML 145价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-107536 | ML 145 ML 145 | 1164500-72-4 | 5mg | 1200元 |
| 2024/04/30 | HY-107536 | ML 145 ML 145 | 1164500-72-4 | 10mM * 1mLin DMSO | 1320元 |
| 2024/04/30 | HY-107536 | ML 145 ML 145 | 1164500-72-4 | 10mg | 2000元 |
常见问题列表
生物活性
ML 145 是选择性，竞争性的人 GPR35/CXCR8 拮抗剂，IC50/EC50 为 20.1 nM。ML 145 对 GPR35 的选择性比 GPR55 (IC50/EC50=21.7 μM) 高超 1000 倍。 ML 145 对啮齿动物直系同源物的 GPR35 均无明显活性。靶点
IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55)
体外研究
ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate.
ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs.
ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC
50
value against EC
80
concentrations of various GPR35 agonists in the region of 20 nM.