117041-96-0

中文名称 TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS

英文名称 Trisodium (2RS,3RS)-2-methylcitrate

CAS 117041-96-0

分子式 C7H7O7*3Na

分子量 230.15

MOL 文件 117041-96-0.mol

117041-96-0 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

2-甲基柠檬酸三钠非标记非对映异构体的混合物 90%+ CP
2-甲基柠檬酸三钠非对映异构体的混合物 (甲基-D3, 98%) 90%+ CP

英文别名

Methylcitric acid trisodium
2-Methylcitric acid trisodium
2-hydroxy-butane-1,2,3-tricarbonoic acid
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
Trisodium 2-methylcitrate, racemic mixture of diastereomers >=85% (mixture of diastereomers, NMR)

物理化学性质

储存条件-20°C储存

形态Solid

颜色White to off-white

安全数据

WGK Germany3

常见问题列表

生物活性

2-Methylcitric acid trisodium (Methylcitric acid trisodium) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid trisodium 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid trisodium 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。

靶点

Human Endogenous Metabolite

体外研究

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca ²⁺ -loaded mitochondria supported by different substrates.
2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.