117423-74-2
117423-74-2 结构式
基本信息
中文别名
化合物 T15803 英文别名
CGS23131LY 223982
SKF107324)
LY223982 Exclusive
SYZSSLLFRVDRHL-QPJJXVBHSA-N
LY223982 (Synonyms: CGS23131
5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid
Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
物理化学性质
熔点151-152 °C
沸点753.8±60.0 °C(Predicted)
密度1.235±0.06 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度氯仿（微溶、加热、超声处理）、DMSO（微溶）
酸度系数(pKa)3.81±0.10(Predicted)
形态结晶固体
颜色White to off-white
常见问题列表
生物活性
LY223982 是一种有效的，特异性的白三烯 B4 受体 (leukotriene B4 receptor)抑制剂，能够有效抑制 [3H]LTB4 与 LTB4 受体结合，IC50 值为 13.2 nM。靶点
|
LTB 4 13.2 nM (IC 50 ) |
体外研究
LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC 50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC 50 , 100 nM).
体内研究
LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED 50 , 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems.