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118021-35-5

中文名称 (S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸赖氨酸
英文名称 O-(2-AMINOETHYL)-L-SERINE HYDROCHLORIDE
CAS 118021-35-5
分子式 C5H13ClN2O3
分子量 184.62
MOL 文件 118021-35-5.mol
118021-35-5 结构式 118021-35-5 结构式

基本信息

中文别名
L-4-噁溶菌素盐酸盐
O-(2-氨乙基)-L-丝氨酸盐酸盐
间-(2-氨基乙基)-L-丝氨酸盐酸盐
(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸赖氨酸
(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸 单盐酸盐
英文别名
L-4-OXALYSINE HCL
H-SER(ETNH2)-OH HCL
H-LYS[*4(<-O)]-OH HCL
4-OXY-L-LYSINE HYDROCHLORIDE
L-4-Oxalysine (hydrochloride)
O-(2-AMINOETHYL)-L-SERINE HYDROCHLORIDE
O-(2-AMINOETHYL)-L-SERINE HYDROCHLORIDE USP/EP/BP
(2S)-2-amino-3-(2-aminoethoxy)propanoicacid,hydrochloride
(S)-(+)-2-AMINO-3-(2-AMINOETHOXY)PROPANOIC ACID, MONOHYDROCHLORIDE
(S)-(+)-2-AMINO-3-(2-AMINOETHOXY)-PROPAN OIC ACID HYDROCHLORIDE, 98%
所属类别
生物化工:赖氨酸类衍生物

物理化学性质

熔点212-216 °C(lit.)
比旋光度+4.0~+8.0°(c=10,dilHCl)(D/20)
储存条件-20°C储存
溶解度溶于二甲基亚砜
形态Solid
颜色White to off-white

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H315-H335-H319
危险品标志Xi
危险类别码36/37/38
安全说明26-36
WGK Germany3
(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸赖氨酸价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-U00097(S)-(+)-2-氨基-3-(2-氨基乙氧基)丙酸赖氨酸
L-4-Oxalysine hydrochloride
118021-35-51mg1000元

常见问题列表

生物活性
L-4-Oxalysine hydrochloride是从中国的链霉菌培养基中分离的天然物质,具有抗癌活性。
体外研究

Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor.

体内研究

Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma.

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