1189561-66-7
1189561-66-7 结构式
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-15464D | (S)-Gossypol (acetic acid) | 1189561-66-7 | 5 mg | 875元 |
| 2025/02/08 | HY-15464D | 1189561-66-7 (S)-Gossypol (acetic acid) | 1189561-66-7 | 10mg | 1400元 |
| 2025/02/08 | HY-15464D | 1189561-66-7 (S)-Gossypol (acetic acid) | 1189561-66-7 | 10mM * 1mLin DMSO | 1540元 |
常见问题列表
|
Bcl-2
|
Bcl-xL
|
The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).