1191908-14-1

中文名称 ADRA1D receptor agonist 1

英文名称 ADRA1D receptor agonist 1

CAS 1191908-14-1

分子式 C15H14Cl2N4O

分子量 337.2

MOL 文件 1191908-14-1.mol

1191908-14-1 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T10250
ADRA1D RECEPTOR ANTAGONIST 1 盐酸盐

英文别名

ADRA1D receptor agonist 1
ADRA1D receptor antagonist 1
ADRA1D receptor antagonist 1 HCl
ADRA-1D receptor antagonist 1,ADRA1D receptor antagonist 1

物理化学性质

形态Solid

颜色Yellow to brown

常见问题列表

生物活性

ADRA1D receptor agonist 1 (compound (R)-9S) 是一个高效、选择性的，有口服活性的 α1D 肾上腺素受拮抗剂，Ki 值为 1.6 nM。

靶点

Ki: 1.6 nM (α _1D adrenoceptor)

体外研究

ADRA1D receptor agonist 1 shows low hERG inhibition.
ADRA1D receptor agonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs .

体内研究

ADRA1D receptor agonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.

Animal Model:	Rat with bladder outlet obstruction (BOO)
Dosage:	4.4 µg/kg
Administration:	Intravenous injection
Result:	Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.