1191995-00-2
中文名称
多格列艾汀
英文名称
(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((R)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-MethylpentanaMide
CAS
1191995-00-2
分子式
C22H27ClN4O5
分子量
462.93
MOL 文件
1191995-00-2.mol
更新日期
2024/07/12 16:06:33
1191995-00-2 结构式
基本信息
中文别名
多格列艾汀多扎格列艾汀
化合物DORZAGLIATIN
(S)-2-(4-(2-氯苯氧基)-2-氧代-2,5-二氢-1H-吡咯-1-基)-N-(1-((R)-2,3-二羟丙基)-1H-吡唑-3-基)-4-甲基戊酰胺
英文别名
RO-5305552DORZAGLIATIN
1191995-00-2
DORZAGLIATIN
SINOGLIATIN
HMS5552
RO5305552
(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((R)-2,3-dihyd
(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((R)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-MethylpentanaMide
diabetes,inhibit,β-cell,Hexokinase IV,Inhibitor,glycaemic,type 2,Hexokinase D,Glucokinase,Dorzagliatin,pancreatic,HMS-5552,HMS 5552
(S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid [1-((R)-2,3-dihydroxy-propyl)-1H-pyrazol-3-yl]-amide
1H-Pyrrole-1-acetamide, 4-(2-chlorophenoxy)-N-[1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl]-2,5-dihydro-α-(2-methylpropyl)-2-oxo-, (αS)-
物理化学性质
沸点761.7±60.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
溶解度DMSO:108.5(Max Conc. mg/mL);234.38(Max Conc. mM)
Ethanol:92.0(Max Conc. mg/mL);198.73(Max Conc. mM)
Ethanol:92.0(Max Conc. mg/mL);198.73(Max Conc. mM)
酸度系数(pKa)12.84±0.70(Predicted)
形态Solid
颜色White to off-white
