1196800-40-4
中文名称
AMADACYCLINE METHANESULFONATE
英文名称
PTK0796 Methanesulfonate
CAS
1196800-40-4
分子式
C29H40N4O7.x(CH4O3S)
分子量
652.756
MOL 文件
1196800-40-4.mol
1196800-40-4 结构式
基本信息
中文别名
化合物 T5189L 英文别名
OMadacycline (Mesylate)PTK0796 Methanesulfonate
PTK-0796 Methanesulfonate
PTK 0796 Methanesulfonate
OMadacycline Methanesulfonate
AMadacycline (Methanesulfonate)
OMADACYCLINE METHANESULFONATE
PTK 0796 METHANESULFONATE
PTK-0796 METHANESULFONATE
PTK0796 METHANESULFONATE
应用领域
用途一
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.