1202710-57-3

中文名称 1202710-57-3

英文名称 GSTO-IN-2

CAS 1202710-57-3

分子式 C33H52N2O9

分子量 620.77

MOL 文件 1202710-57-3.mol

更新日期 2023/03/20 15:41:27

1202710-57-3 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T11504

英文别名

GSTO-IN-2
GSTO inhibitor 2
L-Aspartic acid, L-γ-glutamyl-, 21-[(3α,5β)-23-carboxy-24-norcholan-3-yl] ester

物理化学性质

沸点821.7±65.0 °C(Predicted)

密度1.26±0.1 g/cm3(Predicted)

酸度系数(pKa)2.21±0.10(Predicted)

形态Solid

颜色White to off-white

常见问题列表

生物活性

GSTO-IN-2是一种谷胱甘肽S-转移酶 (glutathione S-transferase) 抑制剂，对于GSTA2，GSTM1和GSTP1-1的 IC50 值分别为3.6，16.3，1.4 μM。

靶点

IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)

体外研究

GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231..