1218-98-0
中文名称
7,8-二氢-D-新蝶呤
英文名称
7,8-DIHYDRONEOPTERIN
CAS
1218-98-0
分子式
C9H13N5O4
分子量
255.23
MOL 文件
1218-98-0.mol
1218-98-0 结构式
基本信息
中文别名
7,8-二氢-D-新蝶呤 英文别名
Dihydroneopterin7,8-DIHYDRONEOPTERIN
7,8-DIHYDRO-D-NEOPTERIN
NEOPTERIN, 7,8-DIHYDRO-D
2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one
2-azanyl-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one
4(3H)-Pteridinone, 2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-
物理化学性质
熔点>167°C (dec.)
沸点614.6±65.0 °C(Predicted)
密度2.03±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度可溶于酸性水溶液（少许）、DMSO（少许）
酸度系数(pKa)9.88±0.20(Predicted)
形态固体
颜色淡黄色
BRN1133875
常见问题列表
生物活性
7,8-Dihydroneopterin 是一种炎症标记，通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元细胞凋亡 (apoptosis)。可用于神经退行性疾病的研究。靶点
Apoptosis; iNOS
体外研究
7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y).
7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes .
Cell Viability Assay
| Cell Line: | Astrocytic cell line U373MG |
| Concentration: | 0.1, 0.5, 1, 2.5, 5 mM |
| Incubation Time: | 2 days and 5 days |
| Result: |
After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM.
After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth. |