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122341-40-6

中文名称 NEUROPEPTIDE Y (13-36) (HUMAN, RAT)
英文名称 NEUROPEPTIDE Y (13-36), HUMAN, RAT
CAS 122341-40-6
分子式 C134H207N41O36S
分子量 3000.4
MOL 文件 122341-40-6.mol
更新日期 2024/07/07 16:58:01
122341-40-6 结构式 122341-40-6 结构式

基本信息

中文别名
NEUROPEPTIDE Y (13-36), HUMAN肽
英文别名
NPY (13-36) (HUMAN, RAT)
Neuropeptide Y(13-36)【rat】
13-36-Human neuropeptide Y
NEUROPEPTIDE Y (13-36) HUMAN
PAEDMARYYSALRHYINLITRQRY-NH2
NEUROPEPTIDE Y (13-36), HUMAN, RAT
13-36-Neuropeptide Y (human) (9CI)
Neuropeptide Y (13-36), amide, human
PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2
H-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2

物理化学性质

密度1.49±0.1 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble in DMSO
形态Solid
颜色White to off-white

常见问题列表

生物活性
Neuropeptide Y (13-36), amide, human 是选择性的神经肽 Y2 受体 (neuropeptide Y2 receptor) 的激动剂。
靶点

NPYY 2 receptor

体内研究

Neuropeptide Y (13-36) (intraventricular injection; 25-3000 pmol) produces a dose-dependent increase (up to 14%; ED 50 value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake, unrestrained male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat.Neuropeptide Y (13-36) (intracerebroventricular injection; 50 ng; alone; injected 30 and 15 min before measurements) injected into naïve mice impairs social novelty preference, but not sociability, and this effect is inhibited by the NPY Y 2 receptor antagonist BIIE 0246.

Animal Model: Male ICR mice (age 4-7 weeks)
Dosage: 50 ng/mouse
Administration: Intracerebroventricular injection
Result: Significantly decreased interaction time with the new stranger mouse in session 3 that NPY 13-36.
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