122752-15-2
中文名称
DELTORPHIN I
英文名称
DELTORPHIN I
CAS
122752-15-2
分子式
C37H52N8O10
分子量
768.86
MOL 文件
122752-15-2.mol
更新日期
2024/07/07 16:57:59
122752-15-2 结构式
基本信息
中文别名
化合物DELTORPHIN I(TFA)D-ALA2] DELTORPHIN I-新皮啡肽
英文别名
Delt-iDELTORPHIN 1
DELTORPHIN C
DELTORPHIN I
Deltorphin Ⅰ
ala(2)-deltorphin
Deltorphin I(TFA)
[D-ALA2]DELTORPHIN I
deltorphin I, Ala(2)-
M.W. 768.87 C37H52N8O10
物理化学性质
沸点1242.4±65.0 °C(Predicted)
密度1.284±0.06 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble to 0.40 mg/ml in 50% acetonitrile / water
酸度系数(pKa)4.19±0.10(Predicted)
形态粉末
颜色White to off-white
常见问题列表
生物活性
Deltorphin I 是一种高亲和力的选择性 δ-阿片受体 (δ-opioid receptor) 激动剂。靶点
δ-opioid receptor
体内研究
Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent.