化合物 T24396价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-110320 | 化合物 T24396 LDN-209929 dihydrochloride | 1233355-57-1 | 1 mg | 727元 |
| 2025/02/08 | HY-110320 | 化合物 T24396 LDN-209929 dihydrochloride | 1233355-57-1 | 10 mM * 1 mLin DMSO | 1428元 |
| 2025/02/08 | HY-110320 | 化合物 T24396 LDN-209929 dihydrochloride | 1233355-57-1 | 5 mg | 1600元 |
常见问题列表
生物活性
LDN-209929 dihydrochloride 是一种有效和选择性的 haspin kinase 抑制剂 (IC50=55 nM)，具有 180 倍的选择性，比 DYRK2 (IC50=9.9 μM)。LDN-209929 是 LDN-192960 (HY-13455) 的优化物。靶点
IC50: 55 nM (haspin kinase)IC50: 9.9 μM (DYRK2)
体外研究
Haspin: Haploid Germ Cell-Specific Nuclear Protein Kinase, is a serine/threonine kinase expressed in a variety of tissues (e.g., testis, bone marrow, thymus, and spleen). Haspin also plays an important role in mitosis, where it phosphorylates histone H3 at Thr-3 (H3T3) in G2/early prophase, becomes maximal during prometaphase/metaphase and then diminishes during anaphase. DYRKs belong to the CMGC family of ePKs and can be further divided into class 1 kinases DYRK1A and 1B, and class 2 kinases DYRK2, 3, and 4. The activity of DYRKs depends upon autophosphorylation of an essential activation loop tyrosine during synthesis.