124265-89-0
![124265-89-0 结构式](/CAS/20180808/GIF/124265-89-0.gif)
物理化学性质
密度1.68±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 230 mg/mL (908.16 mM)
酸度系数(pKa)9.61±0.20(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Omaciclovir (H2G) 是一种有效的选择性疱疹病毒 herpesvirus 复制抑制剂。Omaciclovir 是一种核苷类似物。体外研究
Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys.
Omaciclovir shows antiviral activities against different human herpesviruses with EC
50
s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively.