125-13-3
中文名称
3,3-二(4-羟基苯基)-2(3H)-吲哚酮
英文名称
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
CAS
125-13-3
分子式
C20H15NO3
分子量
317.34
MOL 文件
125-13-3.mol
更新日期
2024/07/12 22:18:51
125-13-3 结构式
基本信息
中文别名
酚汀酚丁
二酚靛红
3,3-二(4-羟基苯基)-2(3H)-吲哚酮
英文别名
isolaxlavema
recolon
hoscolax
neodrast
normalax
veripaque
propellax
phenolisatin
OXYPHENISATIN
所属类别
原料药：泻药止泻药物理化学性质
外观性状结晶。熔点 ＞260℃。
熔点260-261 °C
沸点562.9±50.0 °C(Predicted)
密度1.352±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 28 mg/mL (88.23 mM)
酸度系数(pKa)9.42±0.30(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Oxyphenisatine (Oxyphenisatin) 是一种泻药。 Oxyphenisatin acetate是具有抗癌活性的氧联苯沙星的前体药。体外研究
Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC 50 =0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK.
体内研究
Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52.