12583-68-5
基本信息
牛甲状旁腺激素-(1-34)
特立帕肽-多肽制剂一致性评价
PHT激活剂(TERIPARATIDE)
TERIPARATIDE
PTH (1-34) (BOVINE)
bovineparathyroidhormone(1-34
AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF
PARATHYROID HORMONE (1-34), BOVINE
parathyroid hormone fragment 1-34 bovine
PARATHYROID HORMONE BOVINE: FRAGMENT 1-34
ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE
H-ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-OH
物理化学性质
常见问题列表
Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group.
Cell Proliferation Assay
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.1-100 ng/mL |
| Incubation Time: | 2-20 days |
| Result: | Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal. |
Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls.