125974-72-3
中文名称
茚托利辛
英文名称
Intoplicine
CAS
125974-72-3
分子式
C21H24N4O
分子量
348.44
MOL 文件
125974-72-3.mol
更新日期
2023/03/20 15:41:19
125974-72-3 结构式
基本信息
中文别名
茚托利辛 英文别名
Intoplicine7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl-
11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole
物理化学性质
熔点216-218 °C
沸点635.5±55.0 °C(Predicted)
密度1.286±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)8.26±0.30(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Intoplicine 是 DNA 拓扑异构酶 I 和 II 抑制剂。靶点
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Topoisomerase I
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Topoisomerase II
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体外研究
Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex.