1260181-14-3
基本信息
TCS 21311
TCS21311
TCS-21311
JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione
3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-
物理化学性质
应用领域
常见问题列表
JAK3 8 nM (IC 50 ) |
JAK2 2.55 μM (IC 50 ) |
JAK1 1.017 μM (IC 50 ) |
PKCα 13 nM (IC 50 ) |
PKCθ 68 nM (IC 50 ) |
GSK-3β 3 nM (IC 50 ) |
TCS 21311 (NIBR3049) exhibits IC 50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay. TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC 50 =689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.