1262131-60-1
中文名称
化合物 T27699
英文名称
JTZ-951 hydrochloride
CAS
1262131-60-1
分子式
C17H17ClN4O4
分子量
376.8
MOL 文件
1262131-60-1.mol
1262131-60-1 结构式
应用领域
用途一
Enarodustat, also known as JTZ-951, is a prolyl hydroxylase inhibitor. JTZ-951 (enarodustat) stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor. Enarodustat increases endogenous erythropoietin levels in the treatment of anemia associated with chronic kidney disease (CKD). JTZ-951 induces erythropoiesis without affecting VEGF function. JTZ-951 may be a new oral candidate that increases and maintains hemoglobin concentrations in renal anemia patients.