1268335-33-6

中文名称 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID

英文名称 1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid

CAS 1268335-33-6

分子式 C10H11BO4

分子量 206

MOL 文件 1268335-33-6.mol

1268335-33-6 结构式

基本信息物理化学性质安全数据 1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID价格(试剂级) 常见问题列表

基本信息

英文别名

AN3661
1,3-dihydro-1-hydroxy-2,1-Benzoxaborole-7-propanoic acid
3-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acid
3-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoic acid

物理化学性质

熔点150-151 °C

沸点402.7±55.0 °C(Predicted)

密度1.31±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: 250 mg/mL (1213.59 mM)

酸度系数(pKa)4.52±0.10(Predicted)

形态Solid

颜色White to off-white

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-128204	1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID AN3661	1268335-33-6	5mg	1600元
2024/04/30	HY-128204	1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID AN3661	1268335-33-6	10mM * 1mLin DMSO	1760元
2024/04/30	HY-128204	1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE-7-PROPANOIC ACID AN3661	1268335-33-6	10mg	2600元

常见问题列表

生物活性

AN3661，一种有效的抗疟疾先导化合物，靶向恶性疟原虫的切割和多腺苷酸特异性因子同源物亚基 3 (PfCPSF3)。AN3661 可抑制恶性疟原虫实验室适应的菌株(平均 IC50=32 nM)，Ugandan 野外分离株 (平均 IC50=64 nM) 和小鼠 P. berghei 和 P. falciparum 的感染。

体外研究

AN3661 is active at nanomolar (IC ₅₀ =20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is similarly active in ex vivo studies of fresh Ugandan field isolates (mean ex vivo IC ₅₀ =64 nM). AN3661 shows minimal cytotoxicity against mammalian cell lines, with the CC ₅₀ 60.5 μM against Jurkat cells, and all other CC ₅₀ values greater than the highest concentrations tested (25 μM or above).
AN3661 inhibits the stability of P. falciparum transcripts.

体内研究

AN3661 (50-200 mg.kg; p.o.; daily for 4 days) inhibits murine P. berghei infections with ED ₉₀ (4 days) 0.34 mg/kg.
AN3661 is administered orally for 4 days, beginning on the third day of infection, the ED ₉₀ 4 days after initiation of treatment is 0.57 mg/kg.

Animal Model:	P. berghei -infected mice (malaria model)
Dosage:	50, 100, 200 mg/kg
Administration:	Orally; daily for 4 days
Result:	Rapidly controlled parasitemias, with an ED ₉₀ of 0.34 mg/kg. Daily dosages of 50 mg/kg and 100 mg/kg extended survival, and mice treated with 200 mg/kg per day demonstrated long-term cures.