1268720-28-0
中文名称
7(R)-Maresin 1
英文名称
7(R)-Maresin 1
CAS
1268720-28-0
分子式
C22H32O4
分子量
360.49
MOL 文件
1268720-28-0.mol
更新日期
2023/03/20 15:41:17
1268720-28-0 结构式
基本信息
英文别名
Maresin 17(R)-Maresin 1
HLHYXXBCQOUTGK-FHCQLJOMSA-N
7(R)-Maresin 1 Exclusive
4,8,10,12,16,19-Docosahexaenoic acid, 7,14-dihydroxy-, (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-
物理化学性质
沸点559.4±50.0 °C(Predicted)
密度1.048±0.06 g/cm3(Predicted)
储存条件Store at -80°C, protect from light
溶解度DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml
酸度系数(pKa)4.58±0.10(Predicted)
形态Liquid
颜色Colorless to light yellow
常见问题列表
生物活性
Maresin 1 是人体内源性的 DHA 产生的 特异性调节介质，可以刺激胞内Ca2+ 产生和分泌。Maresin 1 具有抗炎活性。体外研究
Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production.
Cell Viability Assay
| Cell Line: | Neutrophils (2 ╳10 5 cells/well). |
| Concentration: | 300 nM. |
| Incubation Time: | 30 min. |
| Result: | Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well [3] . |
体内研究
Maresin 1 (MaR1) dose-dependently inhibits TRPV1 currents in neurons, blocks capsaicin (100 nM)-induced inward currents (IC
50
=0.49 nM), and reduces both inflammation- and chemotherapy-induced neuropathic pain in mice.
Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis.
| Animal Model: | Male CD1 mice (8-10 wk of age) (colitis was induced by DSS). |
| Dosage: | 0.1, 0.3, and 1 μg/animal. |
| Administration: | Intraocular route once a day from day 0 to day 7. |
| Result: |
MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
|