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127252-80-6

中文名称 克拉霉素杂质O
英文名称 Clarithromycin (9Z)-O-Methyloxime
CAS 127252-80-6
分子式 C39H72N2O13
分子量 776.99
MOL 文件 127252-80-6.mol
更新日期 2024/07/08 16:40:47
127252-80-6 结构式 127252-80-6 结构式

基本信息

中文别名
克拉霉素杂质
克拉霉素杂质O
克拉红霉素 EP杂质O
克拉霉素杂质O(EP)
英文别名
ClarithroMycin Identity
Clarithromycin (9Z)-O-Methyloxime
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z)
Erythromycin, 6-O-methyl-, 9-O-methyloxime, (9Z)-
Clarithromycin Impurity 15(Clarithromycin EP Impurity O)
Clarithromycin EP Impurity O (Clarithromycin (9Z)-O-Methyloxime/ 6-O-Methylerythromycin A (Z)-9-(O-methyloxime))
Clarithromycin EP Impurity O/(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,Z)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-10-(methoxyimino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one

物理化学性质

熔点>116oC (dec.)
沸点812.6±75.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可溶于氯仿(轻微)、甲醇(非常轻微)
酸度系数(pKa)13.02±0.70(Predicted)
形态固体
颜色灰白色至浅米色
稳定性吸湿性
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