1292285-54-1
中文名称
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
英文名称
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
CAS
1292285-54-1
分子式
C14H18N2O3
分子量
262.3
MOL 文件
1292285-54-1.mol
更新日期
2023/03/20 15:41:25
1292285-54-1 结构式
基本信息
中文别名
化合物 T16924 英文别名
SPRi 3SPR inhibitor 3
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy-
物理化学性质
沸点561.9±50.0 °C(Predicted)
密度1.241±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 100 mM,Ethanol: 100 mM
酸度系数(pKa)10.14±0.40(Predicted)
形态固体
颜色Off-white to gray
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-115510 | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide SPR inhibitor 3 | 1292285-54-1 | 5 mg | 1300元 |
2024/08/19 | HY-115510 | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide SPR inhibitor 3 | 1292285-54-1 | 10mM * 1mLin DMSO | 1430元 |
2024/08/19 | HY-115510 | N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide SPR inhibitor 3 | 1292285-54-1 | 10mg | 1850元 |
常见问题列表
生物活性
SPR inhibitor 3 (SPRi3) 是一种有效的 sepiapertin 还原酶 (SPR) 抑制剂。SPR inhibitor 3 (SPRi3) 在非细胞体系中显示出与人 SPR 的高结合亲和力 (IC50=74 nM),在细胞检测中有效降低生物喋呤水平 (IC50=5.2 μM)。SPR inhibitor 3 (SPRi3) 通过降低 BH4 水平减少神经性和炎症性疼痛。靶点
IC50: 74 nM (sepiapterin reductase)
体外研究
SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC 50 =0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1).