129277-38-9
中文名称
党参炔苷
英文名称
Lobetyolin
CAS
129277-38-9
分子式
C20H28O8
分子量
396.43
MOL 文件
129277-38-9.mol
更新日期
2024/02/02 15:50:24
129277-38-9 结构式
基本信息
英文别名
β-D-Glucopyranoside, (1R,2R,7E)-2-hydroxy-1-[(1E)-5-hydroxy-1-pentenyl]-7-nonene-3,5-diynyl (9CI)物理化学性质
沸点698.5±55.0 °C(Predicted)
密度1.35±0.1 g/cm3(Predicted)
酸度系数(pKa)11.39±0.20(Predicted)
形态Solid
颜色White to yellow
常见问题列表
生物活性
Lobetyolin 是一种分离自 Codonopsis pilosula 的生物活性化合物。Lobetyolin 具有抗炎，抗氧化和黄嘌呤氧化酶抑制活性。Lobetyolin 还通过抑制 ASCT2 介导的谷氨酰胺代谢来诱导细胞凋亡。体外研究
Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively.