130112-42-4
中文名称
MIVOTILATE
英文名称
Unii-0789652qul
CAS
130112-42-4
分子式
C12H14N2O3S3
分子量
330.45
MOL 文件
130112-42-4.mol
更新日期
2023/03/20 15:41:25
130112-42-4 结构式
基本信息
中文别名
化合物 T16082 英文别名
Ccris 8109Mivotilate
Unii-0789652qul
Mivotilate [inn]
YH439 >=98% (HPLC)
Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate
Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate
2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester
Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester
物理化学性质
密度1.467±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度二甲基亚砜：≥5mg/mL
酸度系数(pKa)4.89±0.70(Predicted)
形态固体
颜色Light yellow to yellow
MIVOTILATE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 1mg | 1363元 |
| 2024/08/19 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 5mg | 3000元 |
| 2024/08/19 | HY-100242 | MIVOTILATE Mivotilate | 130112-42-4 | 10 mM * 1 mLin DMSO | 3300元 |
常见问题列表
生物活性
Mivotilate 是一种非毒性的，有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂，具有护肝作用。靶点
Aryl hydrocarbon receptor
体外研究
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor.
体内研究
Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats.