131875-08-6

中文名称来沙骨化醇

英文名称 Lexacalcitol

CAS 131875-08-6

分子式 C29 H48 O4

分子量 460.69

MOL 文件 131875-08-6.mol

更新日期 2024/08/24 19:15:45

131875-08-6 结构式

基本信息物理化学性质来沙骨化醇价格(试剂级) 常见问题列表

基本信息

中文别名

来沙骨化醇

英文别名

KH 106
KH 1060
Lexacalcitol
Lenosacalcitol
Lexacalcideferol
(1S*,3R*,5Z),7aalpha))-(5Z,7E,20R)-20-((4-Ethyl-4-hydroxyhexyl)oxy)-9,10-secopregna-5,7,10(19)-triene-1alpha,3beta-diol
1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-
(1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(4-ethyl-4-hydroxyhexoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点600.3±55.0 °C(Predicted)

密度1.07±0.1 g/cm3(Predicted)

储存条件-20°C, protect from light, stored under nitrogen,unstable in solution, ready to use.

溶解度DMSO

酸度系数(pKa)14.43±0.40(Predicted)

形态粉末

颜色White to off-white

来沙骨化醇价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/08/19	HY-32340	来沙骨化醇 Lexacalcitol	131875-08-6	1mg	2560元
2024/08/19	HY-32340	来沙骨化醇 Lexacalcitol	131875-08-6	5mg	6400元
2023/10/26	HY-32340	来沙骨化醇 Lexacalcitol	131875-08-6	10mg	12500元

常见问题列表

生物活性

Lexacalcitol (KH1060) 是一种维生素 D 类似物，是细胞生长和免疫反应的有效调节剂。Lexacalcitol 可用于移植排斥反应、银屑病、癌症和自身免疫性疾病的研究。

体外研究

Lexacalcitol inhibits cell proliferation by 50% at 10 ^-12 M (14,000 times more active than la,25(OH) ₂ D ₃ ) in human histiocytic lymphoma cell line U 937.
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10 ^-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10 ^-15 M.

体内研究

Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients.

Animal Model:	Male and female spontaneously diabetic NOD mice
Dosage:	0.5 mg/kg/2 days
Administration:	Intraperitoneal injection
Result:	Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.