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132996-61-3

中文名称 成骨生长肽
英文名称 OSTEOGENIC GROWTH PEPTIDE
CAS 132996-61-3
分子式 C68H110N22O18
分子量 1523.74
MOL 文件 132996-61-3.mol
更新日期 2024/07/07 16:58:02
132996-61-3 结构式 132996-61-3 结构式

基本信息

中文别名
成骨生长肽
L-丙氨酰-L-亮氨酰-L-赖氨酰-L-精氨酰-L-谷氨酰甘氨酰-L-精氨酰-L-苏氨酰-L-亮氨酰-L-酪氨酰甘氨酰-L-苯丙氨酰甘氨酰-甘氨酸
英文别名
Osteogenic Growth Peptide OGP
OSTEOGENIC GROWTH PEPTIDE USP/EP/BP
Glycine, L-alanyl-L-leucyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-arginyl-L-threonyl-L-leucyl-L-tyrosylglycyl-L-phenylalanylglycyl-
D-Alanyl-L-leucyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-arginyl-L-allothreonyl-L-leucyl-D-tyrosylglycyl-N-benzylglycylglycylglycinamide
所属类别
生物化工:多肽

物理化学性质

储存条件−20°C
形态Solid
颜色White to off-white
成骨生长肽价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-P1563成骨生长肽
Osteogenic Growth Peptide, OGP
132996-61-35mg3900元
2024/04/30HY-P1563成骨生长肽
Osteogenic Growth Peptide, OGP
132996-61-310mg6300元
2024/01/25HY-P1563成骨生长肽
Osteogenic Growth Peptide, OGP
132996-61-31mg1200元

常见问题列表

生物活性
Osteogenic Growth Peptide, OGP 是由 14 个氨基酸残基组成的多肽,是一种对骨髓损伤有系统性应答的促进因子,以 μM 级浓度存在于哺乳动物的血清中。
体外研究

Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH 2 -ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells.

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