1338247-35-0

中文名称 BMS-5

英文名称 N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide

CAS 1338247-35-0

分子式 C17H14Cl2F2N4OS

分子量 431.29

MOL 文件 1338247-35-0.mol

更新日期 2024/07/23 11:54:21

1338247-35-0 结构式

基本信息物理化学性质安全数据 BMS-5价格(试剂级) 常见问题列表

基本信息

中文别名

化合物BMS5
BMS-5游离态

英文别名

LIMKI-3
CS-2190
BMS 5
BMS5
BMS-5 ≥95%
BMS-5， LIMKI-3
LIMKI-3
BMS5
BMS 5
LIMKI3
LIMKI 3
N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-
N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide

物理化学性质

密度1.54±0.1 g/cm3(Predicted)

储存条件Sealed in dry,Store in freezer, under -20°C

溶解度DMSO:PBS (pH 7.2) (1:5):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);6.96(Max Conc. mM)

酸度系数(pKa)9.51±0.50(Predicted)

形态白色粉末

颜色White to off-white

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H312-H332

防范说明P280

BMS-5价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	S0185	BMS-5 BMS-5	1338247-35-0	5mg	857.46元
2024/04/30	S0185	BMS-5 BMS-5	1338247-35-0	25mg	1775.47元
2024/04/30	S0185	BMS-5	1338247-35-0	100mg	6855.74元

常见问题列表

生物活性

BMS-5 (LIMKi 3) 是一种有效的 LIM kinases (LIMK) 的抑制剂，对LIMK1和LIMK2的IC50值分别为7 nM和8 nM。

靶点

Target	Value
LIMK1 (Cell-free assay)	7 nM
LIMK2 (Cell-free assay)	8 nM

体外研究

BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2 ^ΔEx2 mouse Schwann cells (MSCs) with an IC ₅₀ of ~2 µM. BMS-5 (LIMKi 3) reduces Nf2 ^ΔEx2 MSC viability in a dose-dependent manner with an IC ₅₀ of 3.9 µM, but does not significantly reduce the viability of control Nf2 ^flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5, Nf2 ^ΔEx2 MSC viability is 40% compared to 83% for controls.

体内研究

BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).