135330-08-4
中文名称
RP-54745
英文名称
RP 54745
CAS
135330-08-4
分子式
C13H12ClNOS2
分子量
297.82
MOL 文件
135330-08-4.mol
更新日期
2024/11/05 13:11:14
135330-08-4 结构式
基本信息
中文别名
化合物RP-54745 英文别名
RP 547454-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one
3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
物理化学性质
沸点411.4±55.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
储存条件Inert atmosphere,2-8°C
溶解度DMSO : 62.5 mg/mL (209.86 mM);Water : < 0.1 mg/mL (insoluble)
酸度系数(pKa)-2.57±0.40(Predicted)
形态Solid
颜色Light yellow to yellow
常见问题列表
生物活性
RP-54745 是一种潜在的治风湿化合物，能够抑制噬细胞刺激和的白介素-1 (interleukin-1) 的产生。靶点
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IL-1
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体外研究
RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages.
体内研究
RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745.