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1357349-91-7

中文名称 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
英文名称 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 1357349-91-7
分子式 C16H15N5
分子量 277.32
MOL 文件 1357349-91-7.mol
更新日期 2024/07/18 19:57:09
1357349-91-7 结构式 1357349-91-7 结构式

基本信息

中文别名
化合物SPP-86
英文别名
SPP 86
SPP86 >=98% (HPLC)
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-

物理化学性质

沸点495.3±40.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)3.95±0.30(Predicted)
形态Solid
颜色Off-white to light yellow
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-1101931-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
SPP-86
1357349-91-71mg480元
2024/04/30HY-1101931-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
SPP-86
1357349-91-75mg1200元
2024/04/30HY-1101931-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
SPP-86
1357349-91-710mM * 1mLin DMSO1320元

常见问题列表

生物活性
SPP-86 是一种选择性的 RET 酪氨酸激酶的有效抑制剂,其 IC50 值为 8 nM。SPP-86 抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路,也能抑制 RET 诱导的 ERα 磷酸化。
靶点

IC50: 8 nM (RET).

体外研究

SPP86 (0-10 μM) inhibits MAPK signaling and proliferation in RET/PTC1 expressing TPC1 but not 8505C or C643 cells.
SPP86 (0-10 μM) inhibits RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells.

Western Blot Analysis

Cell Line: Thyroid cancer derived cell lines expressing the RET/PTC1 rearrangement (TPC1), BRAF V600E (8505C) or RAS G13R (C643) mutations.
Concentration: 0-10 μM.
Incubation Time: 90 min.
Result: Inhibited RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines.

Western Blot Analysis

Cell Line: MCF7 cells (human breast cancer).
Concentration: 0-10 μM.
Incubation Time: 30 min.
Result: Inhibited RET- induced ERα phosphorylation and proliferation in MCF7 cells.
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