1357349-91-7
中文名称
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
英文名称
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS
1357349-91-7
分子式
C16H15N5
分子量
277.32
MOL 文件
1357349-91-7.mol
更新日期
2024/07/18 19:57:09
![1357349-91-7 结构式](/CAS/20200331/GIF/1357349-91-7.gif)
基本信息
中文别名
化合物SPP-86 英文别名
SPP 86SPP86 >=98% (HPLC)
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
物理化学性质
沸点495.3±40.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)3.95±0.30(Predicted)
形态Solid
颜色Off-white to light yellow
1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 1mg | 480元 |
2024/04/30 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 5mg | 1200元 |
2024/04/30 | HY-110193 | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine SPP-86 | 1357349-91-7 | 10mM * 1mLin DMSO | 1320元 |
常见问题列表
生物活性
SPP-86 是一种选择性的 RET 酪氨酸激酶的有效抑制剂,其 IC50 值为 8 nM。SPP-86 抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路,也能抑制 RET 诱导的 ERα 磷酸化。靶点
IC50: 8 nM (RET).
体外研究
SPP86 (0-10 μM) inhibits MAPK signaling and proliferation in RET/PTC1 expressing TPC1 but not 8505C or C643 cells.
SPP86 (0-10 μM) inhibits RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells.
Western Blot Analysis
Cell Line: | Thyroid cancer derived cell lines expressing the RET/PTC1 rearrangement (TPC1), BRAF V600E (8505C) or RAS G13R (C643) mutations. |
Concentration: | 0-10 μM. |
Incubation Time: | 90 min. |
Result: | Inhibited RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines. |
Western Blot Analysis
Cell Line: | MCF7 cells (human breast cancer). |
Concentration: | 0-10 μM. |
Incubation Time: | 30 min. |
Result: | Inhibited RET- induced ERα phosphorylation and proliferation in MCF7 cells. |