136609-26-2
136609-26-2 结构式
基本信息
中文别名
化合物 T12767化合物RP 70676
RP 70676游离态
英文别名
RP 706761H-Pyrazole, 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl-
所属类别
生物化工：抑制剂物理化学性质
沸点605.9±57.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)11.80±0.10(Predicted)
形态固体
颜色白色至灰白色
常见问题列表
生物活性
RP 70676 是一种有效的 ACAT 抑制剂，能够抑制对大鼠和兔子中的 ACAT 活性，IC50 值分别为 25 和 44 nM。靶点
IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)
体外研究
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM.
体内研究
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.