136941-70-3

中文名称 136941-70-3

英文名称 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide

CAS 136941-70-3

分子式 C26H24Cl2N2O7S

分子量 579.45

MOL 文件 136941-70-3.mol

136941-70-3 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T10101

英文别名

Calcium channel-modulator-1
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-[3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl] 5-methyl ester

物理化学性质

沸点721.2±70.0 °C(Predicted)

密度1.427±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)2.62±0.70(Predicted)

形态Solid

颜色White to off-white

常见问题列表

生物活性

Calcium channel-modulator-1是钙离子通道 (calcium channel) 调节剂，阻塞主动脉收缩的 IC50 值为0.8 μM。

靶点

IC50: 0.8 μM (Aortic contraction)

体内研究

Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine.