137089-36-2

中文名称 137089-36-2

英文名称 2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide

CAS 137089-36-2

分子式 C20H37NOS

分子量 339.58

MOL 文件 137089-36-2.mol

137089-36-2 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-Decenamide, N-[2-[(2-cyclohexylethyl)thio]ethyl]-, (E)- (9CI)

物理化学性质

沸点503.3±42.0 °C(Predicted)

密度0.954±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)14.50±0.46(Predicted)

常见问题列表

生物活性

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 是一种由压力诱发的溃疡和低毒性抑制剂，可以在压力引起的溃疡大鼠中，维持磷脂酶 A2 (phospholipase A2) 和前列腺素 E2 (prostaglandin E2) 的含量水平。

靶点

PGE ₂

PGI ₂

PLA ₂

体内研究

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (compd.III-1α, 100 mg/kg, p.o.) maintains the relative content of Fr.I hexose, lipid peroxide and phospholipase A2 (PLA2) in normal level in ulcerated rats induced by water immersed restrained stress via dosing twice a day for 3 day (b.i.d. for 3 d). 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (100 mg/kg, p.o.) reduces the hexosamine content equally with the control group 4 h after the stress loading, and then markedly increases 7 h after stress loading. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) blocks the reduction of prostaglandin E2 (PGE2) and PGI2 in early phase and accelerates the increase of PGE2 and PGI2 in the late phase of the stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) also significantly accelerates the cell proliferation in fundic glands in gastric mucosa of mice.