1374663-29-2
![1374663-29-2 结构式](/CAS/20211123/GIF/1374663-29-2.gif)
物理化学性质
储存条件-20°, stored under nitrogen,unstable in solution, ready to use.
溶解度DMSO: 210 mg/mL (596.12 mM)
形态Solid
颜色White to light yellow
常见问题列表
生物活性
Sulfo-ara-F-NMN (CZ-48) 是一种烟酰胺单核苷酸 (NMN) 的类似物。Sulfo-ara-F-NMN 选择性激活 SARM1,但抑制 CD38 (IC50 约为 10 μM)。Sulfo-ara-F-NMN 诱导细胞内环状 ADP-核糖 (cADPR) 的产生。体外研究
Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death.