1375751-08-8
中文名称
化合物 T30545
英文名称
BMS-955829
CAS
1375751-08-8
分子式
C22H14F2N2O2
分子量
376.36
MOL 文件
1375751-08-8.mol
1375751-08-8 结构式
基本信息
中文别名
化合物 T30545 英文别名
BMS-955829(4R,5R)-5-(2,5-DIFLUOROPHENYL)-4-(5-(PHENYLETHYNYL)PYRIDIN-3-YL)OXAZOLIDIN-2-ONE
应用领域
用途一
BMS-955829 is a Positive allosteric modulators (PAMs). BMS-955829 shows high functional PAM potency, excellent mGluR5 binding affinity, low glutamate fold shift, and high selectivity for the mGluR5 subtype. BMS-955829 is a potent mGluR5 PAM (EC50 = 2.6 ± 1.0 nM; n = 6), devoid of inherent mGluR5 agonist activity (EC50 > 30μM). The measured binding Ki of BMS-955829 was found to be 1.6 nM, which was in good agreement with its functional potency.