1380341-99-0
![1380341-99-0 结构式](/CAS/20180808/GIF/1380341-99-0.gif)
基本信息
GAL-021, >98%
GAL021
GAL 021
GAL-021, 1380341-99-0
1,3,5-Triazine-2,4,6-triamine, N2-methoxy-N2-methyl-N4,N6-dipropyl-
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-101422 | GAL-021 | 1380341-99-0 | 5mg | 890元 |
2024/08/19 | HY-101422 | GAL-021 | 1380341-99-0 | 10mM * 1mLin DMSO | 979元 |
2024/08/19 | HY-101422 | GAL-021 | 1380341-99-0 | 10mg | 1300元 |
常见问题列表
GAL-021 is being developed as a novel breathing control modulator to preserve respiratory drive and protect patients from respiratory impairment due to opioids and other modalities. Using inside-out patches in GH3 cells, GAL-021 exerts concentration-dependent inhibition of single-channel KCa1.1 activity. When evaluated against 12 different cardiac ion channels, inhibition is 35% or less at 30 μM. No significant kinase inhibition is observed at 10 μM. At 30 μM in the radioligand binding assays, interactions (defined as >50% radioligand displacement) are detected at adenosine A1 (65% I), A2A (79% I, IC 50 approximately 5μM), and A3 (93% I; IC 50 approximately 1 μM) receptors, at 5-HT2B receptors (60% I; IC 50 approximately 30 μM).
Intravenously administered GAL-021 attenuates opiate-induced respiratory depression in rats and nonhuman primates without affecting morphine analgesia in rats. GAL-021 ventilatory stimulation in rats is attenuated by carotid sinus nerve transection. GAL-021 ventilatory stimulation is attenuated in mice lacking the pore-forming α-subunit of the KCa 1.1 channel.