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138356-21-5

中文名称 BD-1047盐酸盐
英文名称 BD 1047 dihydrobromide
CAS 138356-21-5
分子式 C13H22Br2Cl2N2
分子量 437.041
MOL 文件 138356-21-5.mol
更新日期 2024/06/07 17:53:09
138356-21-5 结构式 138356-21-5 结构式

基本信息

中文别名
N-[2-(3,4-二氯苯基)乙基]-N,N',N'-三甲基-1,2-乙二胺二氢溴酸盐
英文别名
169592
BD1047.2HBr
BD 1047 HBr
BD-1047
BD 1047
BD1047.2HBr(1K/g)
BD 1047 (hydrobromide)
N1-(3,4-DICHLOROPHENETHYL)-N1,N2,N2-TRIMETHYLETHANE-1,2-DIAMINE 2HBR
N1-(3,4-dichlorophenethyl)-N1,N2,N2-trimethylethane-1,2-diamine dihydrobromide
N-[2-(3,4-Dichlorophenyl)ethyl]-N,N',N'-trimethyl-1,2-ethanediamine dihydrobromide
n-[2-(3,4-dichlorophenyl)ethyl]-n,n',n'-trimethylethane-1,2-diamine dihydrobromide
所属类别
生物化工:激动剂抑制剂

物理化学性质

储存条件Inert atmosphere,2-8°C
溶解度在水中的溶解度>5mg/mL
形态粉末
颜色白色
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

安全数据

危险性符号(GHS)
GHS05,GHS07
警示词危险
危险性描述H315-H318-H335
危险品标志Xi
危险类别码37/38-41
安全说明26-36/37
WGK Germany3
BD-1047盐酸盐价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30S0106BD-1047盐酸盐
BD-1047 dihydrobromide
138356-21-55mg753.46元
2024/04/30S0106BD-1047盐酸盐
BD-1047 dihydrobromide
138356-21-525mg2024.47元

常见问题列表

生物活性
BD-1047 dihydrobromide (HBr) 是一种 sigma-1 (σ1) receptor 的选择性的功能拮抗剂,在动物模型中显示出抗精神病活性,可预测对精神分裂症的疗效。
靶点
TargetValue
σ1 receptor
()
体外研究

BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.

体内研究

BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice.
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine).
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity.

Animal Model: Male Albino Swiss mice (50 days old, 25–28 g)
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection
Result: Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.
"138356-21-5" 相关产品信息
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