139225-22-2

中文名称化合物 PANAMESINE

英文名称 (5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one

CAS 139225-22-2

分子式 C23H26N2O6

分子量 426.46

MOL 文件 139225-22-2.mol

139225-22-2 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 PANAMESINE

英文别名

(5S)-5-[(4-benzo[1,3]dioxol-5-yl-4-hydroxy-1-piperidyl)methyl]-3-(4-methoxyphenyl)oxazolidin-2-one
2-Oxazolidinone, 5-[[4-(1,3-benzodioxol-5-yl)-4-hydroxy-1-piperidinyl]methyl]-3-(4-methoxyphenyl)-, (5S)-

物理化学性质

熔点165 °C(Solv: ethanol (64-17-5); dichloromethane (75-09-2))

沸点614.1±55.0 °C(Predicted)

密度1.343±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO : 125 mg/mL (293.11 mM)

酸度系数(pKa)13.84±0.20(Predicted)

形态Solid

颜色Off-white to light yellow

常见问题列表

生物活性

Panamesine (EMD 57445) 是一种高亲和力的 sigma 受体配体，IC50 为 6 nM，有潜力用于非典型抗精神病的研究。

靶点

IC50: 6 nM (sigma receptor)

体内研究

Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex.

Animal Model:	Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g
Dosage:	0.3, 1, 3, 30 mg/kg
Administration:	Subcutanous injections
Result:	Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex.