1417997-93-3
中文名称
MDK-7933
英文名称
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
CAS
1417997-93-3
分子式
C22H19NO3
分子量
345.39
MOL 文件
1417997-93-3.mol
更新日期
2024/09/25 10:08:25
1417997-93-3 结构式
基本信息
中文别名
化合物HDAC8-IN-1(E)-N-羟基-3-(5-甲氧基-[1,1':4',1''-三联苯]-2-基)丙烯酰胺
英文别名
CS-2693MDK-7933
HDAC8-IN-1
HDAC8-IN-22d
HDAC8 inhibitor 1
HDAC8 inhibitor 22d
HDAC8-IN-1 ,MDK7933
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
2-Propenamide, N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-, (2E)-
物理化学性质
密度1?+-.0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度可溶于DMSO
酸度系数(pKa)8.76±0.23(Predicted)
形态固体
颜色White to off-white
常见问题列表
生物活性
HDAC8-IN-1 是一个 HDAC8 抑制剂,其 IC50 值为 27.2 nM。靶点
HDAC8 27.2 nM (IC 50 ) |
体外研究
HDAC8-IN-1 is a HDAC8 inhibitor with an IC 50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells.