1422269-30-4
中文名称
(S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)环己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺
英文名称
ML 18
CAS
1422269-30-4
分子式
C32H35N5O5
分子量
569.65
MOL 文件
1422269-30-4.mol
更新日期
2024/08/02 14:00:33
1422269-30-4 结构式
基本信息
中文别名
化合物ML 18 英文别名
ML 18ML18, >98%
BRS-3 antagonist
ML18
ML-18
ML 18
BRS-3 ANTAGONIST
1422269-30-4
(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
物理化学性质
沸点821.8±65.0 °C(Predicted)
密度1.291±0.06 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度可溶于DMSO
酸度系数(pKa)11.99±0.46(Predicted)
形态固体
颜色White to yellow
常见问题列表
生物活性
ML-18是一种抑制肺癌生长的非肽铃蟾肽受体亚型-3 (BRS-3) 拮抗剂。靶点
IC50: 4.8 μM (BRS-3)
体外研究
ML-18 inhibits specific 125 I-BA1 (DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2)BB6-14 binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC 50 values of 4.8 μM. ML-18 binds with lower affinity to the GRPR and NMBR with IC 50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 10 nM BA1 to elevate cytosolic Ca 2+ in a reversible manner using lung cancer cells loaded with FURA2-AM. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells. It inhibits the proliferation of lung cancer cells.