142439-94-9

中文名称 ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

英文名称 ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

CAS 142439-94-9

分子式 C10H11N5NaO5PS

分子量 367.25

MOL 文件 142439-94-9.mol

更新日期 2023/03/20 15:41:19

142439-94-9 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

RP-CAMPS NA
CAMPS NA RP-ISOMER
RP-CAMPS SODIUM SALT
SP-CYCLIC 3,5-HYDROGEN PHOSPHOROTHIOATE ADENOSINE SODIUM SALT
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

物理化学性质

储存条件Store at -20°C, sealed storage, away from moisture and light

形态Solid

颜色White to pink

常见问题列表

生物活性

Rp-cAMPS sodium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。

靶点

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)

体外研究

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.

体内研究

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.