142523-14-6

中文名称化合物 T11797

英文名称 1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE

CAS 142523-14-6

分子式 C32H52O16P2

分子量 754.69

MOL 文件 142523-14-6.mol

142523-14-6 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T11797

英文别名

L-690,488
L 690488,L690488
1-[(4-HYDROXYPHENOXY)ETHYLIDENE]BIS[PHOSPHINYLIDYNEBIS(OXYMETHYLENE)]-2,2-DIMETHYLPROPANOATE
Propanoic acid, 2,2-dimethyl-, [1-(4-hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)] ester (9CI)

物理化学性质

沸点754.8±60.0 °C(Predicted)

密度1.232±0.06 g/cm3(Predicted)

储存条件Store at -80°C

酸度系数(pKa)9.55±0.15(Predicted)

常见问题列表

生物活性

L-690488 是一种 L-690330 的前药，也是一种选择性的肌醇单磷酸酶 (IMPase) 抑制剂。L-690488 比 L-690330 具有更有效的细胞穿透能力。

靶点

Inositol monophosphatase (IMPase)

体外研究

The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC ₅₀ values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [ ³ H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC ₅₀ values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively).
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion.