1428-67-7
1428-67-7 结构式
基本信息
SC-4473
Diarylpropionitrile
2,3-bis(p-hydroxyphenyl)propionitrile
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
propionitrile,2,3-bis(p-hydroxyphenyl)
2,3-Bis(4-hydroxyphenyl)propanenitrile
2,3-Bis(4-hydroxyphenyl)propiononitrile
2,3-Bis(4-hydroxyphenyl)propionitrile >
Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-
物理化学性质
安全数据
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | B4385 | 2,3-双(4-羟苯基)丙腈 2,3-Bis(4-hydroxyphenyl)propionitrile | 1428-67-7 | 10mg | 480元 |
| 2024/11/08 | B4385 | 2,3-双(4-羟苯基)丙腈 2,3-Bis(4-hydroxyphenyl)propionitrile | 1428-67-7 | 50mg | 1795元 |
常见问题列表
|
ERβ 0.85 nM (EC 50 ) |
DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC
50
=0.85 nM for ERβ; EC
50
=66 nM for ERα).
DPN (10 nM) prevents morphological alterations from Aβ
1-42
(10 μM)-induced toxicity in cultured cortical neurons.
DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner.
DPN (0.1-100 nM) significantly reduces Aβ
1-42
-stimulated expression of Bax in a non-dose dependent manner.
DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ
1-42
treatment on cultured cortical neurons.
DPN (0.1-100 nM) suppresses the Aβ
1-42
-upregulated phosphorylation of JNK and p38.
DPN (10 μg; s.c.; daily; for 11 days) increases swimming and decreases immobility in the FST, and increases TPH protein expression in the dorsal raphe nucleus (DR) in rat model.
| Animal Model: | Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models |
| Dosage: | 10 μg/rat |
| Administration: | Subcutaneous injections, daily, for 11 days |
| Result: | Increased swimming and decreased immobility in the FST. |