142873-41-4

中文名称 142873-41-4

英文名称 5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-

CAS 142873-41-4

分子式 C24H32N2O

分子量 364.52

MOL 文件 142873-41-4.mol

142873-41-4 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

脂质过氧化抑制剂1

英文别名

Lipid peroxidation inhibitor 1
5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-

物理化学性质

沸点520.4±50.0 °C(Predicted)

密度1.090±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)8.09±0.10(Predicted)

常见问题列表

生物活性

Lipid peroxidation inhibitor 1 是一种脂质过氧化 (lipid peroxidation) 抑制剂，其 IC50 值为 0.07 μM。

靶点

IC50: 0.07μM (lipid peroxidation)

体外研究

Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC ₅₀ of 0.07 μM.

体内研究

Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective.