142873-41-4
中文名称
142873-41-4
英文名称
5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-
CAS
142873-41-4
分子式
C24H32N2O
分子量
364.52
MOL 文件
142873-41-4.mol
![142873-41-4 结构式](/CAS/20180601/GIF/142873-41-4.gif)
基本信息
中文别名
脂质过氧化抑制剂1 英文别名
Lipid peroxidation inhibitor 15-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-
物理化学性质
沸点520.4±50.0 °C(Predicted)
密度1.090±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)8.09±0.10(Predicted)
常见问题列表
生物活性
Lipid peroxidation inhibitor 1 是一种脂质过氧化 (lipid peroxidation) 抑制剂,其 IC50 值为 0.07 μM。靶点
IC50: 0.07μM (lipid peroxidation)
体外研究
Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC 50 of 0.07 μM.
体内研究
Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective.