1430218-51-1
中文名称
1430218-51-1
英文名称
VI16832
CAS
1430218-51-1
分子式
C22H25N5O2
分子量
391.47
MOL 文件
1430218-51-1.mol
更新日期
2024/06/17 17:25:38
1430218-51-1 结构式
基本信息
中文别名
I型激酶抑制剂(VI 16832) 英文别名
VI16832Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-[[4-(2-aminoethoxy)phenyl]amino]-8-bicyclo[2.2.1]hept-2-yl-
物理化学性质
沸点611.9±65.0 °C(Predicted)
密度1.337±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 83.3 mg/mL (212.79 mM)
酸度系数(pKa)8.57±0.10(Predicted)
形态Solid
颜色Light yellow to yellow
1430218-51-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-18623 | 1430218-51-1 VI 16832 | 1430218-51-1 | 1mg | 990元 |
| 2024/08/19 | HY-18623 | 1430218-51-1 VI 16832 | 1430218-51-1 | 5mg | 3150元 |
| 2024/08/19 | HY-18623 | 1430218-51-1 VI 16832 | 1430218-51-1 | 10mM * 1mLin DMSO | 3465元 |
常见问题列表
生物活性
VI 16832 是一种广谱的 I 型激酶抑制剂，可用作不同癌细胞系中蛋白激酶比较表达分析的富集工具。靶点
Type I kinase
体外研究
VI 16832 is a broad spectrum Type I kinase inhibitor. Phosphoproteomics analysis of VI 16832-enriched fractions from MV4-11, HCT116, or 435S cells results in more than 8500 phosphopeptide identifications. These translate into almost 1700 distinct phosphopeptide species derived from 212 different members of the protein kinase superfamily. Analysis of VI 16832-retained proteins from the three cancer cell lines considerably increases the overall number of identified phosphorylation sites on protein kinases. Considering the sum of all phosphopeptide intensities as a measure for VI 16832-enriched protein amount, more than 80% is derived from protein kinases.