1430741-35-7
1430741-35-7 结构式
基本信息
中文别名
化合物 T30804 英文别名
CFI401870CFI-401870
1H-Indazole-5-carboxamide, N-[(R)-cyclopropyl-2-pyridinylmethyl]-3-[4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]phenyl]-
应用领域
用途一
CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) Inhibitor (TTK IC50 < 10 nM, HCT116 GI50 < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation.