143584-75-2
中文名称
143584-75-2
英文名称
S-methyl-KE-298
CAS
143584-75-2
更新日期
2024/07/21 13:45:52
分子式
C13H16O3S
分子量
252.33
MOL 文件
143584-75-2.mol
143584-75-2 结构式
物理化学性质
沸点457.2±45.0 °C(Predicted)
密度1.188±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)4.11±0.23(Predicted)
形态Solid
颜色White to off-white
143584-75-2价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2021/03/30 | S0300 | 143584-75-2 S-methyl-KE-298 | 143584-75-2 | 5mg | 3988.53元 |
| 2021/03/30 | S0300 | 143584-75-2 S-methyl-KE-298 | 143584-75-2 | 25mg | 12031.1元 |
常见问题列表
生物活性
S-methyl-KE-298 是 KE-298 的一种活性代谢物。KE-298 抑制类风湿关节炎 (RA) 滑膜细胞的基质金属蛋白酶 (MMP-1) 产生。体外研究
S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells.