1451362-51-8
中文名称
3-氧代-1-苯基-2,7,10,13,16-五氧杂-4-氮杂十八烷-18-酸
英文名称
CbzNH-PEG4-CH2COOH
CAS
1451362-51-8
分子式
C18H27NO8
分子量
385.41
MOL 文件
1451362-51-8.mol
1451362-51-8 结构式
基本信息
中文别名
3-氧代-1-苯基-2,7,10,13,16-五氧杂-4-氮杂十八烷-18-酸 英文别名
CbzNH-PEG4-CH2COOH3-Oxo-1-phenyl-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid, 1-(phenylmethyl) ester
应用领域
用途一
CbzNH-PEG4-CH2COOH is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.