145196-87-8
中文名称
Iodophenpropit dihydrobromide
英文名称
Iodophenpropit dihydrobromide
CAS
145196-87-8
分子式
C15H19IN4S.2HBr
分子量
495.22
MOL 文件
145196-87-8.mol
145196-87-8 结构式
物理化学性质
储存条件-20°C储存
溶解度DMSO:50.0(Max Conc. mg/mL);86.79(Max Conc. mM)
Water:32.2(Max Conc. mg/mL);55.89(Max Conc. mM)
Water:32.2(Max Conc. mg/mL);55.89(Max Conc. mM)
形态粉末
颜色White to off-white
水溶解性Soluble to 25 mM in water
常见问题列表
生物活性
Iodophenpropit dihydrobromide 是一种有效的选择性组胺 H3 受体 (histamine H3 receptor) 拮抗剂。[125I] Iodophenpropit 结合 H3 受体具有选择性，可饱和，易于可逆，及高亲和力 (KD 为 0.32 nM)。靶点
|
H 3 Receptor 0.32 nM (Kd) |
体外研究
Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor.
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC
50
of 1.57±0.3 μM.
体内研究
Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits.
| Animal Model: | New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg |
| Dosage: | 1 μg/kg |
| Administration: | Administered through intramuscular (i.m.); b.i.d.; for 10 days |
| Result: | Could influence a detectable antibody response to SRBC. |